![]() ![]() Folate was significantly associated with lower risk of incident GA among subjects homozygous for the complement component 3 (C3) R102G rs2230199 nonrisk genotype (CC) (HR = 0.43 95% CI: 0.27, 0.70 P = 0.0005) but not subjects carrying the risk allele (G) (P = 0.76). Riboflavin did not retain statistical significance (P-trend = 0.20). After adjustment for demographic, behavioral, ocular, and genetic covariates, trends remained statistically significant for folate (P-trend = 0.007) and were borderline for thiamin (P-trend = 0.05). There was a reduced risk of progression to GA with increasing intake of thiamin, riboflavin, and folate after adjusting for age, sex, and total energy intake (P-trend = 0.01, 0.03, and 0.001, respectively). Subjects with at least one eye free of advanced AMD at baseline were included in these analyses. Interaction effects between these nutrients and genetic variation on AMD risk were also evaluated. ![]() Survival analysis was used to assess associations between incident GA and dietary intake of folate and B vitamins. Folate and B vitamins were log transformed and calorie adjusted separately for men and women. ![]() We investigated associations between dietary folate, B vitamins, and progression to GA and whether these associations might be modified by genetic susceptibility.Īmong 2525 subjects (4663 eyes) in the Age-Related Eye Disease Study, 405 subjects (528 eyes) progressed to GA over 13 y. No effective therapeutic strategy for geographic atrophy (GA) is available, and prevention could be of great value. There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but few studies have explored associations with folate and B vitamins. ![]()
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